{"id":11,"date":"2022-01-30T18:02:05","date_gmt":"2022-01-30T10:02:05","guid":{"rendered":"http:\/\/guid"},"modified":"2022-09-08T17:19:02","modified_gmt":"2022-09-08T09:19:02","slug":"%e8%81%94%e7%b3%bb","status":"publish","type":"page","link":"http:\/\/www.chinrilymedica.cn\/?page_id=11","title":{"rendered":"\u7814\u7a76\u62a5\u544a"},"content":{"rendered":"\r\n\t\t<div class=\"pfc-posts-main\">\r\n\r\n\t\t\t\r\n\t\t\t\t<div class=\"pfc-post layout-one\">\r\n\t\t\t\t\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"news-thumb\">\r\n\r\n\t\t\t\t\t\t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=862\"><img loading=\"lazy\" decoding=\"async\" width=\"3269\" height=\"645\" src=\"http:\/\/www.chinrilymedica.cn\/wp-content\/uploads\/2022\/09\/\u7b80\u62a5.png\" class=\"attachment-full size-full wp-post-image\" alt=\"\" \/><\/a>\r\n\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"news-text-wrap info-with-space\">\r\n\r\n\t\t\t\t\t    <h2><a href=\"http:\/\/www.chinrilymedica.cn\/?p=862\">CRM-2102\u5bf9\u5c0f\u9f20\u6d77\u9a6c\u548c\u76ae\u5c42PP2A\u8868\u8fbe\u6c34\u5e73\u7684\u5f71\u54cd<\/a><\/h2>\r\n\r\n\t\t\t\t\t    \t\t\t\t\t    \t<span class=\"posted-date\">2022\u5e7410\u670815\u65e5<\/span>\r\n\t\t\t\t\t    \t<p>CRM-2102\u5bf9\u5c0f\u9f20\u6d77\u9a6c\u548c\u76ae\u5c42PP2A\u7684\u5f71\u54cd \u76ee\u7684 \u7814\u7a76CRM-2102\u5bf9\u5c0f\u9f20\u6d77\u9a6c\u3001\u76ae\u5c42PP2A\u7684\u5f71\u54cd\u3002\u65b9\u6cd5 \u901a\u8fc7\u5411\u5c0f\u9f20\u4fa7\u8111\u5ba4\u6ce8\u5c04A\u03b21-42\u5efa\u7acb\u5c0f\u9f20\u8bb0\u5fc6\u635f\u5bb3\u6a21\u578b\uff0c\u4ee5\u5242\u91cf1.5 mg\/kg\u30014.5 mg\/kg\u300113.5 mg\/kg CRM-2102\u8fde\u7eed\u704c\u80c3\u7ed9\u836f\u4e24\u5468\uff0cWestern Blot\u68c0\u6d4b\u6d77\u9a6c\u548c\u76ae\u5c42\u4e2dPP2A\u8868\u8fbe\u6c34\u5e73\u3002\u7ed3\u679c \u4e0e\u6a21\u578b\u7ec4\u76f8\u6bd4\uff0c\u5242\u91cf\u4e3a13.5 mg\/kg CRM-2102\u7ed9\u836f\u7ec4\u5c0f\u9f20\u6d77\u9a6c\u4e2dPP2A\u8868\u8fbe\u663e\u8457\u589e\u52a0\uff0c\u6709\u7edf\u8ba1\u5b66\u5dee\u5f02\uff08P&lt;0.05\uff09\uff0c\u5242\u91cf\u4e3a1.5 mg\/kg\u30014.5 mg\/kg CRM-2102\u7ed9\u836f\u7ec4\u5c0f\u9f20\u6d77\u9a6c\u4e2dPP2A\u8868\u8fbe\u589e\u52a0\uff0c\u4f46\u65e0\u7edf\u8ba1\u5b66\u5dee\u5f02\uff08P&gt;0.05\uff09\u3002\u5404\u7ec4\u5c0f\u9f20\u76ae\u5c42\u4e2dPP2A\u8868\u8fbe\u6c34\u5e73\u5747\u65e0\u7edf\u8ba1\u5b66\u5dee\u5f02\uff08P&gt;0.05\uff09\u3002\u7ed3\u8bba \u5242\u91cf\u4e3a13.5 mg\/kg CRM-2102\u80fd\u663e\u8457\u589e\u52a0A\u03b21-42\u5c0f\u9f20\u8bb0\u5fc6\u635f\u5bb3\u6a21\u578b\u6d77\u9a6c\u4e2dPP2A\u8868\u8fbe\u3002<\/p>\n\t                \t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=862\" class=\"read-more\">Read More<\/a>\r\n\t                \t\t\t\t\t\t     \r\n\t\t\t\t\t<\/div><!-- .news-text-wrap -->\r\n\r\n\t\t\t\t<\/div>\r\n\r\n\t\t\t\t\r\n\t\t\t\t<div class=\"pfc-post layout-one\">\r\n\t\t\t\t\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"news-thumb\">\r\n\r\n\t\t\t\t\t\t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=839\"><img loading=\"lazy\" decoding=\"async\" width=\"3269\" height=\"645\" src=\"http:\/\/www.chinrilymedica.cn\/wp-content\/uploads\/2022\/09\/\u7b80\u62a5.png\" class=\"attachment-full size-full wp-post-image\" alt=\"\" \/><\/a>\r\n\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"news-text-wrap info-with-space\">\r\n\r\n\t\t\t\t\t    <h2><a href=\"http:\/\/www.chinrilymedica.cn\/?p=839\">CRM-2102\u5bf9\u5188\u7530\u9178\u8bf1\u5bfcSH-SY5Y\u7ec6\u80detau\u86cb\u767d\u78f7\u9178\u5316\u7684\u5f71\u54cd<\/a><\/h2>\r\n\r\n\t\t\t\t\t    \t\t\t\t\t    \t<span class=\"posted-date\">2022\u5e749\u670820\u65e5<\/span>\r\n\t\t\t\t\t    \t<p>CRM-2102\u5bf9\u5188\u7530\u9178\u8bf1\u5bfcSH-SY5Y\u7ec6\u80detau\u86cb\u767d\u78f7\u9178\u5316\u7684\u5f71\u54cd \u76ee\u7684: \u7814\u7a76 CRM-2102 \u5bf9\u5188\u7530\u9178\uff08OA\uff09\u8bf1\u5bfc tau \u86cb\u767d\u78f7\u9178\u5316\u7684\u5f71\u54cd\u3002 \u65b9\u6cd5: \u4f53\u5916\u57f9\u517b SH-SY5Y \u7ec6\u80de\uff0c\u7528\u4e0d\u540c\u6d53\u5ea6(0.1-10\u03bcmol\/L)\u7684\u542b\u836f\u57f9\u517b\u57fa\u5904\u7406\u7ec6\u80de 24 h\uff0c\u518d\u7528 40 nmol\/L OA \u5904\u7406\u7ec6\u80de 24 h\uff0c\u6536\u96c6\u7ec6\u80de\uff0c\u91c7\u7528 Western Blot\u6d4b\u5b9a\u5404\u7ec4\u7ec6\u80de p-tauSer396\u6c34\u5e73\u3002 \u7ed3\u679c\uff1a \u4e0e\u9634\u6027\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c 1\u3001 3\u3001 10 \u03bcmol\/LCRM-2102 \u7ec4\u7ec6\u80de p-tauSer396\u6c34\u5e73\u663e\u8457\u4e0b\u964d\uff08P&lt;0.05\uff09\uff0c 0.1\u3001 0.3 \u03bcM CRM-2102\u7ec4\u7ec6\u80de p-tauSer396\u6c34\u5e73\u4e0b\u964d\uff0c\u4f46\u65e0\u663e\u8457\u6027\u5dee\u5f02\uff08P&gt;0.05\uff09\u3002 \u7ed3\u8bba\uff1a 1-10 \u03bcmol\/LCRM-2102 \u80fd\u6291\u5236 OA \u8bf1\u5bfc\u7684\u7ec6\u80de tau \u86cb\u767d\u78f7\u9178\u5316\u3002<\/p>\n\t                \t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=839\" class=\"read-more\">Read More<\/a>\r\n\t                \t\t\t\t\t\t     \r\n\t\t\t\t\t<\/div><!-- .news-text-wrap -->\r\n\r\n\t\t\t\t<\/div>\r\n\r\n\t\t\t\t\r\n\t\t\t\t<div class=\"pfc-post layout-one\">\r\n\t\t\t\t\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"news-thumb\">\r\n\r\n\t\t\t\t\t\t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=830\"><img loading=\"lazy\" decoding=\"async\" width=\"3269\" height=\"645\" src=\"http:\/\/www.chinrilymedica.cn\/wp-content\/uploads\/2022\/09\/\u7b80\u62a5.png\" class=\"attachment-full size-full wp-post-image\" alt=\"\" \/><\/a>\r\n\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"news-text-wrap info-with-space\">\r\n\r\n\t\t\t\t\t    <h2><a href=\"http:\/\/www.chinrilymedica.cn\/?p=830\">CRM-2102\u5bf9\u5188\u7530\u9178\u8bf1\u5bfc\u7684PC12\u7ec6\u80de\u86cb\u767d\u78f7\u9178\u9176\u8868\u8fbe\u7684\u5f71\u54cd<\/a><\/h2>\r\n\r\n\t\t\t\t\t    \t\t\t\t\t    \t<span class=\"posted-date\">2022\u5e749\u670816\u65e5<\/span>\r\n\t\t\t\t\t    \t<p>\u5bf9\u5188\u7530\u9178\u8bf1\u5bfcPC12\u7ec6\u80de\u86cb\u767d\u78f7\u9178\u9176\u7684\u6d3b\u6027\u5f71\u54cd \u76ee\u7684\uff1a \u7814\u7a76CRM-2102\u5bf9\u5188\u7530\u9178\uff08OA\uff09\u8bf1\u5bfc\u7684\u86cb\u767d\u78f7\u9178\u9176\uff08PP2A\uff09\u8868\u8fbe\u6c34\u5e73\u7684\u5f71\u54cd\u3002\u65b9\u6cd5\uff1a \u4f53\u5916\u57f9\u517bPC12\u7ec6\u80de\uff0c\u7528\u4e0d\u540c\u6d53\u5ea6\u7684\u542bCRM-2102\u5b75\u80b22h\uff0c\u518d\u52a0\u516540nmol\/L OA\u5b75\u80b224h\uff0c\u6536\u96c6\u7ec6\u80de\u548c\u63d0\u53d6\u86cb\u767d\u3002\u91c7\u7528Western Blot\u6cd5\u68c0\u6d4b\u5404\u7ec6\u80de\u5185PP2A\u8868\u8fbe\u6c34\u5e73\u3002\u7ed3\u679c\uff1a 1\u30015\u548c10\u03bcmol\/L CRM-2102\u7ec4PP2A\u8868\u8fbe\u6c34\u5e73\u5206\u522b\u4e3a14%\u300118%\u548c29%\u3002\u9634\u6027\u5bf9\u7167\u4e3a8%\uff0c\u6b63\u5e38\u5bf9\u7167\u4e3a37%\u3002\u7ed3\u8bba\uff1a CRM-2102\u80fd\u63d0\u9ad8\u7531OA\u8bf1\u5bfc\u6291\u5236PC12\u7ec6\u80dePP2A\u86cb\u767d\u8868\u8fbe\u6c34\u5e73\uff0cPP2A\u86cb\u767d\u8868\u8fbe\u6c34\u5e73\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u7684\u63d0\u9ad8\u3002<\/p>\n\t                \t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=830\" class=\"read-more\">Read More<\/a>\r\n\t                \t\t\t\t\t\t     \r\n\t\t\t\t\t<\/div><!-- .news-text-wrap -->\r\n\r\n\t\t\t\t<\/div>\r\n\r\n\t\t\t\t\r\n\t\t\t\t<div class=\"pfc-post layout-one\">\r\n\t\t\t\t\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"news-thumb\">\r\n\r\n\t\t\t\t\t\t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=779\"><img loading=\"lazy\" decoding=\"async\" width=\"3269\" height=\"645\" src=\"http:\/\/www.chinrilymedica.cn\/wp-content\/uploads\/2022\/09\/\u7b80\u62a5.png\" class=\"attachment-full size-full wp-post-image\" alt=\"\" \/><\/a>\r\n\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"news-text-wrap info-with-space\">\r\n\r\n\t\t\t\t\t    <h2><a href=\"http:\/\/www.chinrilymedica.cn\/?p=779\">A\u03b2 \u548c CRM-2102 \u5bf9 PC12 \u7ec6\u80de\u86cb\u767d\u78f7\u9178\u9176(PP2A)\u6d3b\u6027\u7684\u5f71\u54cd<\/a><\/h2>\r\n\r\n\t\t\t\t\t    \t\t\t\t\t    \t<span class=\"posted-date\">2022\u5e749\u67089\u65e5<\/span>\r\n\t\t\t\t\t    \t<p>PP2A;\u6fc0\u52a8\u5242<\/p>\n\t                \t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=779\" class=\"read-more\">Read More<\/a>\r\n\t                \t\t\t\t\t\t     \r\n\t\t\t\t\t<\/div><!-- .news-text-wrap -->\r\n\r\n\t\t\t\t<\/div>\r\n\r\n\t\t\t\t\r\n\t\t<\/div>\r\n\r\n\t\t\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"class_list":["post-11","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/pages\/11","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11"}],"version-history":[{"count":23,"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/pages\/11\/revisions"}],"predecessor-version":[{"id":772,"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/pages\/11\/revisions\/772"}],"wp:attachment":[{"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}