{"id":130,"date":"2022-02-07T17:16:58","date_gmt":"2022-02-07T09:16:58","guid":{"rendered":"http:\/\/110.40.240.150\/wordpress\/?page_id=130"},"modified":"2022-03-10T11:06:18","modified_gmt":"2022-03-10T03:06:18","slug":"%e6%b5%8b%e8%af%952","status":"publish","type":"page","link":"http:\/\/www.chinrilymedica.cn\/?page_id=130","title":{"rendered":"\u5b66\u672f\u4ea4\u6d41"},"content":{"rendered":"\n<hr class=\"wp-block-separator aligncenter has-text-color has-background has-ast-global-color-0-background-color has-ast-global-color-0-color is-style-default\"\/>\n\n\n\n<p><\/p>\n\n\n\r\n\t\t<div class=\"pfc-posts-main\">\r\n\r\n\t\t\t\r\n\t\t\t\t<div class=\"pfc-post layout-one\">\r\n\t\t\t\t\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"news-thumb\">\r\n\r\n\t\t\t\t\t\t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=974\"><img loading=\"lazy\" decoding=\"async\" width=\"3269\" height=\"645\" src=\"http:\/\/110.40.240.150:80\/wp-content\/uploads\/2022\/02\/\u4ea4\u6d41.png\" class=\"attachment-full size-full wp-post-image\" alt=\"\" \/><\/a>\r\n\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"news-text-wrap info-with-space\">\r\n\r\n\t\t\t\t\t    <h2><a href=\"http:\/\/www.chinrilymedica.cn\/?p=974\">\u300a\u4e2d\u56fd\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u84dd\u76ae\u4e662024\u300b\u6b63\u5f0f\u53d1\u5e03<\/a><\/h2>\r\n\r\n\t\t\t\t\t    \t\t\t\t\t    \t<span class=\"posted-date\">2024\u5e747\u670819\u65e5<\/span>\r\n\t\t\t\t\t    \t<p>\u4e2d\u56fd\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u84dd\u76ae\u4e66\uff08\u7cbe\u7b80\u7248\uff09 \u8be5\u6587\u6e90\u4e8e\u7f51\u7edc\uff0c\u5982\u6709\u4fb5\u6743\u8bf7\u544a\u77e5\u6813\u9664\uff01 \u76ee\u524d\u6211\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(NMPA)\u6279\u51c6\u7528\u4e8e\u6cbb\u7597AD\u7684\u4e00\u7ebf\u836f\u7269\u5305\u62ec\u80c6\u78b1\u916f\u9176\u6291\u5236\u5242\uff0c\u5982\u591a\u5948\u54cc\u9f50\u3001\u5361\u5df4\u62c9\u6c40\u7b49\uff0c\u4ee5\u53caN-\u7532\u57fa-D-\u95e8\u51ac\u6c28\u9178(N-methyl-D-asparticacid,NMDA)\u53d7\u4f53\u62ee\u6297\u5242\u7f8e\u91d1\u521a\u30022019\u5e74NMPA\u6709\u6761\u4ef6\u6279\u51c6\u4e86\u7518\u9732\u7279\u94a0\u80f6\u56ca\u4e0a\u5e02\u6ce8\u518c\u7533\u8bf7\uff0c\u7528\u4e8e\u6cbb\u7597\u8f7b\u5ea6\u81f3\u4e2d\u5ea6AD\u30022024\u5e741\u6708\u4ed1\u5361\u5948\u5355\u6297(lecanemab)\u6ce8\u5c04\u6db2\u83b7NMPA\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u7531AD\u5f15\u8d77\u7684\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u548c\u8f7b\u5ea6\u75f4\u5446\uff0c\u8be5\u836f\u662f\u9776\u5411\u62ee\u6297\u805a\u96c6\u7684\u53ef\u6eb6\u6027\u548c\u4e0d\u6eb6\u6027B-\u6dc0\u7c89\u6837\u86cb\u767d(beta-amyloid\uff0cAB)\u7684\u4e00\u79cd\u4eba\u6e90\u5316\u514d\u75ab\u7403\u86cb\u767d1gG1\u5355\u514b\u9686\u6297\u4f53\uff0c\u53ef\u51cf\u5c11A\u03b2\u6591\u5757\u6c89\u79ef\u3002 \u5728\u4e34\u5e8a\u4e0a\u5176\u4ed6\u8f85\u52a9\u836f\u7269\u5305\u62ec\u5965\u62c9\u897f\u5766\u3001\u5421\u62c9\u897f\u5766\u3001\u8111\u86cb\u767d\u6c34\u89e3\u7269\u3001\u94f6\u674f\u53f6\u63d0\u53d6\u7269\u7247\u7b49\u7528\u4e8e\u534f\u540c\u6cbb\u7597\u591a\u79cd\u539f\u56e0\u5bfc\u81f4\u7684\u8001\u5e74\u671f\u75f4\u5446\uff0c\u4f46\u7f3a\u4e4f\u9ad8\u8d28\u91cf\u7684\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\u3002\u9488\u5bf9AD\u5f15\u8d77\u7684\u7cbe\u795e\u548c\u884c\u4e3a\u75c7\u72b6\uff0c\u53ef\u9009\u62e9...<\/p>\n\t                \t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=974\" class=\"read-more\">Read More<\/a>\r\n\t                \t\t\t\t\t\t     \r\n\t\t\t\t\t<\/div><!-- .news-text-wrap -->\r\n\r\n\t\t\t\t<\/div>\r\n\r\n\t\t\t\t\r\n\t\t\t\t<div class=\"pfc-post layout-one\">\r\n\t\t\t\t\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"news-thumb\">\r\n\r\n\t\t\t\t\t\t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=951\"><img loading=\"lazy\" decoding=\"async\" width=\"3269\" height=\"645\" src=\"http:\/\/110.40.240.150:80\/wp-content\/uploads\/2022\/02\/\u4ea4\u6d41.png\" class=\"attachment-full size-full wp-post-image\" alt=\"\" \/><\/a>\r\n\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"news-text-wrap info-with-space\">\r\n\r\n\t\t\t\t\t    <h2><a href=\"http:\/\/www.chinrilymedica.cn\/?p=951\">\u57fa\u4e8e\u5188\u7530\u9178\u4e2d\u5fc3\u7247\u6bb5\uff08C19-C27\uff09\u8bbe\u8ba1\u65b0pp2a\u6d3b\u5316\u7684\u836f\u7269\uff0c\u4e3aAD\u65b0\u836f\u5f00\u53d1\u5f00\u8f9f\u65b0\u9014\u5f84<\/a><\/h2>\r\n\r\n\t\t\t\t\t    \t\t\t\t\t    \t<span class=\"posted-date\">2023\u5e7412\u67087\u65e5<\/span>\r\n\t\t\t\t\t    \t<p>C-glycosides analogues of the okadaic acid central fragment exert \u86cb\u767d\u78f7\u9178\u91762A \u6d3b\u6027\u7684\u4efb\u4f55\u7f3a\u9677\u90fd\u662f\u5bfc\u81f4\u4e25\u91cd\u75c5\u7406\u7684\u539f\u56e0\u3002\u4f8b\u5982\uff0c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u4e3b\u8981\u7ec4\u7ec7\u75c5\u7406\u5b66\u7279\u5f81\u4e4b\u4e00\u662f\u795e\u7ecf\u539f\u7ea4\u7ef4\u7f20\u7ed3\uff0c\u5b83\u4eec\u4e3b\u8981\u7531\u8fc7\u5ea6\u78f7\u9178\u5316\u7684tau\u86cb\u767d\u7ec4\u6210\u3002\u8fd9\u79cdtau\u78f7\u9178\u5316\u7684\u53d8\u5316\u4e0ePP2A\u6d3b\u6027\u6291\u5236\u53caAD\u60a3\u8005\u76f8\u5173\u3002 \u8fd9\u662fRaquel L. Arribas\u7b49\u897f\u73ed\u7259\u7814\u7a76\u8005\u4eca\u5e74\uff082023\u5e74\uff09\u521a\u53d1\u8868\u7684\u7814\u7a76\u6210\u679c\u3002 PP2A\u6291\u5236\u5242\u5188\u7530\u9178(OA)\u7684\u4e2d\u5fc3\u7247\u6bb5C19-C27\uff0c\u8fd9\u4e2a\u4e2d\u5fc3\u90e8\u5206\u4e0d\u53d1\u6325\u6291\u5236\u4f5c\u7528\uff0c\u4f46\u80fd\u4e0ePP2A\u6291\u5236\u5242\u7ade\u4e89\uff0c\u4ece\u800c\u6062\u590d\u78f7\u9178\u9176\u6d3b\u6027\u3002\u8bc1\u660e\u4e86\u8fd9\u4e2a\u5047\u8bbe\u5316\u5408\u7269\u5728\u4e0ePP2A\u635f\u4f24\u76f8\u5173\u7684\u795e\u7ecf\u53d8\u6027\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u826f\u597d\u7684\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u3002 \u5176\u4e2d\u5316\u5408\u7269ITH12711\u901a\u8fc7\u78f7\u9178\u5316\u80bd\u5e95\u7269\u548cwestern-blot\u5206\u6790\u6d4b\u5b9a\uff0c\u80fd\u591f\u589e\u52a0PP2A\u7684\u50ac\u5316\u6d3b\u6027\uff1b\u901a\u8fc7PAMPA\u6d4b\u91cf\u8bc1\u660e\u5177\u6709\u826f\u597d\u7684\u8111\u7a7f\u900f\u6027\uff1b\u80fd\u591f\u589e\u5f3a...<\/p>\n\t                \t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=951\" class=\"read-more\">Read More<\/a>\r\n\t                \t\t\t\t\t\t     \r\n\t\t\t\t\t<\/div><!-- .news-text-wrap -->\r\n\r\n\t\t\t\t<\/div>\r\n\r\n\t\t\t\t\r\n\t\t\t\t<div class=\"pfc-post layout-one\">\r\n\t\t\t\t\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"news-thumb\">\r\n\r\n\t\t\t\t\t\t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=921\"><img loading=\"lazy\" decoding=\"async\" width=\"3269\" height=\"645\" src=\"http:\/\/110.40.240.150:80\/wp-content\/uploads\/2022\/02\/\u4ea4\u6d41.png\" class=\"attachment-full size-full wp-post-image\" alt=\"\" \/><\/a>\r\n\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"news-text-wrap info-with-space\">\r\n\r\n\t\t\t\t\t    <h2><a href=\"http:\/\/www.chinrilymedica.cn\/?p=921\">\u5177\u6709\u6781\u9ad8\u7684\u6dc0\u7c89\u6837\u86cb\u767d\u6591\u5757\u8d1f\u8377\u6c34\u5e73\u7684\u5bb6\u65cf\u6027AD\u60a3\u8005\uff0c\u76f4\u523067\u5c81\u4ecd\u4fdd\u6301\u6b63\u5e38\u8ba4\u77e5\u6c34\u5e73<\/a><\/h2>\r\n\r\n\t\t\t\t\t    \t\t\t\t\t    \t<span class=\"posted-date\">2023\u5e745\u670817\u65e5<\/span>\r\n\t\t\t\t\t    \t<p>s41591-023-02318-3 \u300a\u81ea\u7136.\u533b\u5b66\u300b\uff082023 May 15.doi: 10.1038\/s41591-023-02318-3\uff09\u53d1\u8868\u4e86\u4e00\u7bc7\u8bba\u6587\uff0c\u7814\u7a76\u8005\u5bf9\u4e16\u754c\u7b2c\u4e8c\u4f8b\u5bf9\u5bb6\u65cf\u6027AD\u5177\u6709\u6297\u6027\u7684\u75c5\u4f8b\u8fdb\u884c\u4e86\u5206\u6790\u3002\u8be5\u7537\u6027\u60a3\u8005\u4e3a\u5e38\u67d3\u8272\u4f53\u663e\u6027\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08ADAD\uff09\u57fa\u56e0PSEN1\u00a0E280A\u57fa\u56e0\u643a\u5e26\u8005\uff0c\u4ed6\u8111\u5185\u5177\u6709\u6781\u9ad8\u7684\u6dc0\u7c89\u6837\u86cb\u767d\u6591\u5757\u8d1f\u8377\u6c34\u5e73\uff0ctau\u86cb\u767d\u7ea4\u7ef4\u7f20\u7ed3\u4e5f\u6709\u9887\u9ad8\u6c34\u5e73\uff0c\u4f46\u76f4\u523067\u5c81\u4ecd\u4fdd\u6301\u6b63\u5e38\u8ba4\u77e5\u6c34\u5e73\u3002 \u4ece\u67d0\u79cd\u89d2\u5ea6\u6765\u8bf4\uff0c\u8fd9\u4e2a\u75c5\u4f8b\u5e26\u6765\u7684\u65b0\u53d1\u73b0\u5927\u5927\u6311\u6218\u4e86AD\u4e3b\u8981\u7531A\u03b2\u9a71\u52a8\u7684\u5047\u8bf4\u3002\u8fd9\u540d\u60a3\u8005\u5728\u5177\u6709\u9ad8\u6c34\u5e73A\u03b2\u75c5\u7406\u7684\u60c5\u51b5\u4e0b\u4ecd\u4fdd\u6301\u4e86\u957f\u65f6\u95f4\u7684\u6b63\u5e38\u8ba4\u77e5\uff0c\u7814\u7a76\u8005\u53d1\u73b0\u4ed6\u643a\u5e26\u4e00\u79cd\u5177\u6709\u4fdd\u62a4\u6027\u7684\u7f55\u89c1\u7a81\u53d8RELN\u00a0H3447R\u57fa\u56e0\u3002\u8be5\u7a81\u53d8\u4e3a\u529f\u80fd\u83b7\u5f97\u6027\u7a81\u53d8\uff0c\u5176\u8868\u8fbe\u4ea7\u7269\u80fd\u591f\u66f4\u5f3a\u5730\u6fc0\u6d3b\u4e0b\u6e38\u9776\u70b9\u5e76\u51cf\u5c11tau\u86cb\u767d\u78f7\u9178\u5316\u3002 \u00a0 \u00a0 \u00a0 \u00a0 \u6587\u732e\u6765\u6e90\u4e8e\u516c\u5f00\u53d1\u8868\u7684\u7814\u7a76\u8bba\u6587\uff0c\u5982\u6709\u4fb5\u6743\uff0c\u544a\u77e5\u5373\u6813\u53bb\uff01 \u8fd9\u9879\u7814\u7a76\u7ed3\u679c\u63d0\u793a\u4f5c\u4e3a\u86cb\u767d\u78f7\u9178\u91762A(PP...<\/p>\n\t                \t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=921\" class=\"read-more\">Read More<\/a>\r\n\t                \t\t\t\t\t\t     \r\n\t\t\t\t\t<\/div><!-- .news-text-wrap -->\r\n\r\n\t\t\t\t<\/div>\r\n\r\n\t\t\t\t\r\n\t\t\t\t<div class=\"pfc-post layout-one\">\r\n\t\t\t\t\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"news-thumb\">\r\n\r\n\t\t\t\t\t\t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=904\"><img loading=\"lazy\" decoding=\"async\" width=\"3269\" height=\"645\" src=\"http:\/\/110.40.240.150:80\/wp-content\/uploads\/2022\/02\/\u4ea4\u6d41.png\" class=\"attachment-full size-full wp-post-image\" alt=\"\" \/><\/a>\r\n\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"news-text-wrap info-with-space\">\r\n\r\n\t\t\t\t\t    <h2><a href=\"http:\/\/www.chinrilymedica.cn\/?p=904\">\u5efa\u7acb\u6548\u5e94\u5668\u4e3a\u9776\u4f4d\u52a8\u7269\u6a21\u578b\u80fd\u5426\u6210\u4e3aALS\u836f\u7269\u5f00\u53d1\u65b0\u9014\u5f84\uff1f<\/a><\/h2>\r\n\r\n\t\t\t\t\t    \t\t\t\t\t    \t<span class=\"posted-date\">2022\u5e7412\u670813\u65e5<\/span>\r\n\t\t\t\t\t    \t<p>\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\uff08ALS\uff09\u4e5f\u53eb\u8fd0\u52a8\u795e\u7ecf\u5143\u75c5\uff08MND\uff09\uff0c\u662f\u4e00\u79cd\u5177\u6709\u9009\u62e9\u6027\u5730\u635f\u5bb3\u810a\u9ad3\u524d\u89d2\u3001\u8111\u5e72\u8fd0\u52a8\u795e\u7ecf\u6838\u7684\u8fdb\u884c\u6027\u75be\u75c5\uff0c\u968f\u7740\u8fd0\u52a8\u795e\u7ecf\u5143\u7684\u53d8\u6027\u4e0e\u4e27\u5931\uff0c\u4f7f\u5f97\u75c5\u4eba\u9664\u4e86\u773c\u775b\u4e0e\u5927\u5c0f\u4fbf\u7684\u63a7\u5236\u808c\u8089\u5916\uff0c\u5176\u4ed6\u7684\u808c\u8089\u7686\u4f1a\u53d7\u5230\u5f71\u54cd\u3002 ALS\u75c5\u56e0\u81f3\u4eca\u4e0d\u660e\uff0c\u6bd4\u8f83\u516c\u8ba4\u6700\u76f8\u5173\u7684\u56e0\u7d20\u662f\u5e74\u9f84\u548c\u9057\u4f20\u3002\u4e3b\u8981\u81f4\u75c5\u7406\u8bba\u6709\u8c37\u6c28\u9178\u635f\u4f24\u3001\u81ea\u7531\u57fa\u635f\u4f24\u3001\u795e\u7ecf\u751f\u957f\u56e0\u5b50\u7f3a\u4e4f\u7b49\u51e0\u79cd\u5047\u8bf4\u3002 ALS\u52a8\u7269\u6a21\u578b\u4e3b\u8981\u6709SOD1\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\uff0cSOD1\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u51fa\u73b0\u5927\u91cf\u8fd0\u52a8\u795e\u7ecf\u5143\u6b7b\u4ea1\uff0c\u8fd9\u4e0eSOD1\u6297\u6c27\u5316\u529f\u80fd\u76f8\u543b\u5408\u3002 \u73b0\u6709\u6570\u636e\u8868\u660e\u4ec5\u67095%\u7684\u75c5\u4f8b\u53ef\u80fd\u4e0e\u9057\u4f20\u53ca\u57fa\u56e0\u7f3a\u9677\u6709\u5173\uff0c\u4e14\u670920\u591a\u4e2a\u57fa\u56e0\u88ab\u5217\u5165ALS\u7684\u5143\u51f6\u540d\u5355\uff0c\u4ec5\u6709\u7ea620%\u7684\u9057\u4f20\u6027ALS\u4e0e\u8d85\u6c27\u5316\u7269\u6b67\u5316\u91761\uff08SOD1\uff09\u76f8\u5173\u3002 \u56e0\u6b64\uff0c\u57fa\u4e8eSOD1\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u6a21\u578b\u5f00\u53d1\u7684ALS\u65b0\u836f\u6050\u96be\u5728\u4e34\u5e8a\u4e0a\u83b7\u5f97\u6210\u529f\u3002 ALS\u75c5\u4eba\u8f85\u52a9\u68c0\u67e5\u53d1\u73b0\uff1a 1\u3001\u75c5\u4eba\u6ca1\u6709\u611f\u89c9\u969c\u788d\uff1b 2\u3001\u808c\u7535\u56fe\u5448\u795e\u7ecf\u539f\u6027\u635f\u5bb3\u8868\u73b0\uff0c\u53ef\u89c1\u7ea4\u98a4\u3001\u7535\u4f4d\u5f02\u5e38\uff0c\u4f46\u8fd0\u52a8\u795e\u7ecf\u4f20\u5bfc\u901f\u5ea6\u591a\u6b63\u5e38\uff1b...<\/p>\n\t                \t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=904\" class=\"read-more\">Read More<\/a>\r\n\t                \t\t\t\t\t\t     \r\n\t\t\t\t\t<\/div><!-- .news-text-wrap -->\r\n\r\n\t\t\t\t<\/div>\r\n\r\n\t\t\t\t\r\n\t\t\t\t<div class=\"pfc-post layout-one\">\r\n\t\t\t\t\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"news-thumb\">\r\n\r\n\t\t\t\t\t\t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=854\"><img loading=\"lazy\" decoding=\"async\" width=\"3269\" height=\"645\" src=\"http:\/\/110.40.240.150:80\/wp-content\/uploads\/2022\/02\/\u4ea4\u6d41.png\" class=\"attachment-full size-full wp-post-image\" alt=\"\" \/><\/a>\r\n\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"news-text-wrap info-with-space\">\r\n\r\n\t\t\t\t\t    <h2><a href=\"http:\/\/www.chinrilymedica.cn\/?p=854\">\u78f7\u9178\u9176PP2A\u7684\u7ed3\u6784\u91cd\u8981\u6027\u3001\u8c03\u63a7\u53ca\u5176\u4f5c\u7528\u764c\u75c7\u4e2d\u7684\u5f02\u5e38\u8868\u8fbe<\/a><\/h2>\r\n\r\n\t\t\t\t\t    \t\t\t\t\t    \t<span class=\"posted-date\">2022\u5e749\u670828\u65e5<\/span>\r\n\t\t\t\t\t    \t<p>\u78f7\u9178\u9176PP2A\u7684\u7ed3\u6784\u91cd\u8981\u6027\u3001\u8c03\u63a7\u53ca\u5176\u4f5c\u7528\u764c\u75c7\u4e2d\u7684\u5f02\u5e38\u8868\u8fbe PP2A\u662f\u7ec6\u80de\u7cfb\u7edf\u4e2d\u5fc5\u4e0d\u53ef\u5c11\u7684\u591a\u79cd\u78f7\u9178\u9176\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0cPP2A\u5df2\u77e5\u53ef\u8c03\u828230\u591a\u79cd\u4e0d\u540c\u7684\u6d3b\u6027\u6fc0\u9176\u3002\u91cd\u8981\u7684\u6fc0\u9176\uff0c\u5982\u86cb\u767d\u6fc0\u9176B (AKT)\uff0c PKC, p70 S6\u6fc0\u9176\uff0ccAMP\u4f9d\u8d56\u6027\u6fc0\u9176\u3001cam\u6fc0\u9176\u3001ERK\/MAP\u6fc0\u9176\u662fPP2A\u7684\u4e3b\u8981\u5e95\u7269\u3002\u5728\u7ec6\u80de\u5468\u671f\u8fdb\u5c55\u548c\u51cb\u4ea1\u8fc7\u7a0b\u4e2d\uff0c\u5404\u79cd\u86cb\u767d\u8d28\uff0c\u5982Cdc25, Cdc6, Wee 1\uff0c DNA\u805a\u5408\u9176\u5f15\u7269\u9176\u3001TAU\u86cb\u767d\u548c\u7ec6\u80de\u5468\u671f\u86cb\u767dG2\u4e5f\u53d7PP2A\u63a7\u5236\u3002 \u5728\u4e00\u822c\u6765\u8bf4\uff0cPP2A\u7684\u751f\u7269\u5b66\u7531\u4e8e\u5176\u591a\u6837\u6027\u800c\u66f4\u52a0\u590d\u6742\uff0c\u96be\u4ee5\u7406\u89e3\u5728\u4e0d\u540c\u7ec4\u7ec7\u4e2d\u8868\u8fbe\u5dee\u5f02\u7684\u8c03\u8282\u4e9a\u57fa\u3002\u80bf\u7624PP2A\u7684\u6291\u5236\u4f5c\u7528\u4e3b\u8981\u53d7\u8fd9\u4e9b\u53d1\u6325\u4e0d\u540c\u4f5c\u7528\u7684\u8c03\u63a7\u4e9a\u57fa\u7684\u63a7\u5236\u4e0d\u540c\u5355\u5143\u4e2d\u7684\u89d2\u8272\u3002\u56e0\u4e3a\u8c03\u63a7\u4e9a\u57fa\u7684\u5f02\u6784\u4f53\u8868\u8fbe\u4e0d\u540c\u5728\u4e0d\u540c\u7684\u7ec4\u7ec7\u4e2d\uff0c\u5bf9\u6bcf\u4e00\u79cd\u4e9a\u578b\u8fdb\u884c\u66f4\u8be6\u7ec6\u7684\u7814\u7a76\u5c06\u7cbe\u786e\u5730\u52fe\u753b\u51fa\u7406\u89e3\u8868\u8fbe\u6a21\u5f0f\uff0c\u5e2e\u52a9\u6211\u4eec\u7406\u89e3\u5b83\u4eec\u5728PP2A\u4e2d\u7684\u4f5c\u7528\u63a7\u5236\u4fe1\u53f7\u8f6c\u5bfc\u3002 \u6b64\u5916\uff0cPP2A\u652f\u67b6\u4e9a\u57fa\u5728\u4e24\u8005...<\/p>\n\t                \t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=854\" class=\"read-more\">Read More<\/a>\r\n\t                \t\t\t\t\t\t     \r\n\t\t\t\t\t<\/div><!-- .news-text-wrap -->\r\n\r\n\t\t\t\t<\/div>\r\n\r\n\t\t\t\t\r\n\t\t\t\t<div class=\"pfc-post layout-one\">\r\n\t\t\t\t\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"news-thumb\">\r\n\r\n\t\t\t\t\t\t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=847\"><img loading=\"lazy\" decoding=\"async\" width=\"3269\" height=\"645\" src=\"http:\/\/110.40.240.150:80\/wp-content\/uploads\/2022\/02\/\u4ea4\u6d41.png\" class=\"attachment-full size-full wp-post-image\" alt=\"\" \/><\/a>\r\n\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"news-text-wrap info-with-space\">\r\n\r\n\t\t\t\t\t    <h2><a href=\"http:\/\/www.chinrilymedica.cn\/?p=847\">\u86cb\u767d\u78f7\u9178\u9176\u6fc0\u52a8\u5242\u80fd\u6210\u4e3a\u4e0d\u8001\u836f\u5417\uff1f<\/a><\/h2>\r\n\r\n\t\t\t\t\t    \t\t\t\t\t    \t<span class=\"posted-date\">2022\u5e749\u670827\u65e5<\/span>\r\n\t\t\t\t\t    \t<p>\u4e00\u79cd\u4fdd\u5b88\u7684\u957f\u8ddd\u79bb\u7aef\u7c92\u6c89\u9ed8\u673a\u5236\u6291\u5236\u4e86\u8870\u8001\u7684\u4eba\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684mTOR\u4fe1\u53f7\u901a\u8def \u8bba\u6587\u6458\u8981\uff1a\u7aef\u7c92\u662f\u4f4d\u4e8e\u6bcf\u6761\u67d3\u8272\u4f53\u672b\u7aef\u7684\u91cd\u590d\u7684\u6838\u82f7\u9178\u5e8f\u5217\u3002\u6709\u4eba\u5047\u8bbe\u7aef\u7c92\u78e8\u635f\u5728\u5927\u578b\u957f\u5bff\u7269\u79cd\u4e2d\u8fdb\u5316\u4e3a\u4e00\u79cd\u80bf\u7624\u6291\u5236\u673a\u5236\u3002\u957f\u7aef\u7c92\u53ef\u4ee5\u6c89\u9ed8\u901a\u8fc7\u4e00\u79cd\u53eb\u505a\u7aef\u7c92\u4f4d\u7f6e\u6548\u5e94\u7684\u957f\u8ddd\u79bb\u5faa\u73af\u673a\u5236\uff0c\u6570\u767e\u4e07\u78b1\u57fa\u4e4b\u5916\u7684\u57fa\u56e0(TPE-OLD)\u3002\u8fd9\u79cd\u6d88\u58f0\u673a\u5236\u7684\u529f\u80fd\u5c1a\u4e0d\u6e05\u695a\u3002\u6211\u4eec\u786e\u5b9a\u4e86\u4e00\u7ec42322\u4e2a\u9ad8\u590d\u5236\u8001\u5316\u7269\u79cd\u7684\u4f4d\u7f6e\u5b88\u6052\uff0c\u5305\u62ec\u5df2\u77e5\u548c\u5019\u9009\u7684TPE-OLD\u57fa\u56e0\u53ef\u80fd\u51cf\u8f7b\u590d\u5236\u6027\u8870\u8001\u7684\u6f5c\u5728\u6709\u5bb3\u5f71\u54cd\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6211\u4eec\u53d1\u73b0PPP2R2C\u662f\u4e00\u79cd\u80bf\u7624\u6291\u5236\u56e0\u5b50\u8be5\u57fa\u56e0\u5728\u8001\u5e74\u4eba\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u88abTPE-OLD\u4e0a\u8c03\uff0c\u5bfc\u81f4p70S6\u6fc0\u9176\u53bb\u78f7\u9178\u5316\u548c\u96f7\u5e15\u9709\u7d20\u6291\u5236\u7684\u54fa\u4e73\u52a8\u7269\u9776\u70b9\u3002\u7aef\u7c92\u548c\u80bf\u7624\u6291\u5236\u673a\u5236\u4e4b\u95f4\u7684\u673a\u5236\u8054\u7cfb\u652f\u6301\u4e86\u590d\u5236\u6027\u8870\u8001\u5c65\u884c\u80bf\u7624\u6291\u5236\u529f\u80fd\u548c\u6fc0\u53d1\u7684\u5047\u8bf4\u4ee5\u524d\u672a\u77e5\u7684\u6297\u80bf\u7624\u548c\u6297\u8870\u8001\u7b56\u7565\u3002 \u6587\u732e\u6765\u6e90\u4e8e\u516c\u5f00\u53d1\u8868\u7684\u7814\u7a76\u8bba\u6587\uff0c\u5982\u6709\u4fb5\u6743\uff0c\u544a\u77e5\u5373\u6813\u53bb\uff01 \u65e9\u57282008\u5e74\uff0c\u65bd\u4e00\u516c\u535a\u58eb\u548cJeffry Stock\u6559...<\/p>\n\t                \t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=847\" class=\"read-more\">Read More<\/a>\r\n\t                \t\t\t\t\t\t     \r\n\t\t\t\t\t<\/div><!-- .news-text-wrap -->\r\n\r\n\t\t\t\t<\/div>\r\n\r\n\t\t\t\t\r\n\t\t\t\t<div class=\"pfc-post layout-one\">\r\n\t\t\t\t\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"news-thumb\">\r\n\r\n\t\t\t\t\t\t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=733\"><img loading=\"lazy\" decoding=\"async\" width=\"3269\" height=\"645\" src=\"http:\/\/110.40.240.150:80\/wp-content\/uploads\/2022\/02\/\u4ea4\u6d41.png\" class=\"attachment-full size-full wp-post-image\" alt=\"\" \/><\/a>\r\n\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"news-text-wrap info-with-space\">\r\n\r\n\t\t\t\t\t    <h2><a href=\"http:\/\/www.chinrilymedica.cn\/?p=733\">PP2A\u80fd\u591f\u6210\u4e3a\u6297\u764c\u4f5c\u7528\u7684\u6709\u6548\u9776\u4f4d\u5417\uff1f<\/a><\/h2>\r\n\r\n\t\t\t\t\t    \t\t\t\t\t    \t<span class=\"posted-date\">2022\u5e749\u67085\u65e5<\/span>\r\n\t\t\t\t\t    \t<p>PP2A\uff1b\u6297\u764c<\/p>\n\t                \t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=733\" class=\"read-more\">Read More<\/a>\r\n\t                \t\t\t\t\t\t     \r\n\t\t\t\t\t<\/div><!-- .news-text-wrap -->\r\n\r\n\t\t\t\t<\/div>\r\n\r\n\t\t\t\t\r\n\t\t\t\t<div class=\"pfc-post layout-one\">\r\n\t\t\t\t\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"news-thumb\">\r\n\r\n\t\t\t\t\t\t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=191\"><img loading=\"lazy\" decoding=\"async\" width=\"3269\" height=\"645\" src=\"http:\/\/110.40.240.150:80\/wp-content\/uploads\/2022\/02\/\u4ea4\u6d41.png\" class=\"attachment-full size-full wp-post-image\" alt=\"\" \/><\/a>\r\n\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"news-text-wrap info-with-space\">\r\n\r\n\t\t\t\t\t    <h2><a href=\"http:\/\/www.chinrilymedica.cn\/?p=191\">\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6cbb\u7597\u836f\u7684\u7814\u7a76\u8fdb\u5c55<\/a><\/h2>\r\n\r\n\t\t\t\t\t    \t\t\t\t\t    \t<span class=\"posted-date\">2022\u5e742\u67087\u65e5<\/span>\r\n\t\t\t\t\t    \t<p>\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff1b\u8001\u5e74\u75f4\u5446\u75c7\uff1b\u7efc\u8ff0<\/p>\n\t                \t\t<a href=\"http:\/\/www.chinrilymedica.cn\/?p=191\" class=\"read-more\">Read More<\/a>\r\n\t                \t\t\t\t\t\t     \r\n\t\t\t\t\t<\/div><!-- .news-text-wrap -->\r\n\r\n\t\t\t\t<\/div>\r\n\r\n\t\t\t\t\r\n\t\t<\/div>\r\n\r\n\t\t\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"class_list":["post-130","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/pages\/130","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=130"}],"version-history":[{"count":16,"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/pages\/130\/revisions"}],"predecessor-version":[{"id":296,"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/pages\/130\/revisions\/296"}],"wp:attachment":[{"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=130"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}