{"id":191,"date":"2022-02-07T18:32:33","date_gmt":"2022-02-07T10:32:33","guid":{"rendered":"http:\/\/110.40.240.150\/wordpress\/?p=191"},"modified":"2022-09-08T10:30:10","modified_gmt":"2022-09-08T02:30:10","slug":"%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e6%b2%bb%e7%96%97%e8%8d%af%e7%9a%84%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"http:\/\/www.chinrilymedica.cn\/?p=191","title":{"rendered":"\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6cbb\u7597\u836f\u7684\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"\r\n

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\u7f8e\u56fd\u5e03\u83b1\u6839\u5987\u5973\u533b\u9662\uff08Brigham and Women\u2019s Hospital\uff09\u4e8e2021\u5e7411\u670816\u65e5\uff0c\u5ba3\u5e03\u5c06\u542f\u52a8\u4e00\u98791\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u8bc4\u4f30\u4e00\u79cd\u65b0\u578b\u9f3b\u8154\u75ab\u82d7Protollin\u5728\u9884\u9632\u548c\u51cf\u7f13\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u8fdb\u5c55\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002Protollin<\/a>\u662f\u4e00\u79cd\u7528\u4e8e\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u65b0\u578b\u514d\u75ab\u523a\u6fc0\u7597\u6cd5\u5236\u5242\uff0c\u7531\u7279\u6b8a\u7ec6\u83cc\u7684\u5916\u819c\u86cb\u767d\u548c\u8102\u591a\u7cd6\u7ec4\u6210\uff0cProtollin\u65e8\u5728\u6fc0\u6d3b\u5728\u9888\u90e8\u4e24\u4fa7\u548c\u80cc\u90e8\u6dcb\u5df4\u7ed3\u4e2d\u53d1\u73b0\u7684\u767d\u7ec6\u80de\uff0c\u4ee5\u8fc1\u79fb\u5230\u5927\u8111\u5e76\u89e6\u53d1\u03b2\u6dc0\u7c89\u6837\u6591\u5757\uff08\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u6807\u5fd7\u4e4b\u4e00\uff09\u7684\u6e05\u9664\u3002<\/p>\r\n\r\n\r\n\r\n

\u53c2\u8003\u6587\u732e<\/p>\r\n\r\n\r\n\r\n

1. Sannbria-Castro A et al.<\/a> Molecular pathogenesis of Alzheimer\uff07s disease: an update\uff0e Annals of neurosciences\uff0c2017\uff0c 24( 1) : 46-54.<\/p>\r\n\r\n\r\n\r\n

Guo T et al.Roles of tau protein in health and disease\uff0e Acta neuropathologica\uff0c 2017\uff0c 133( 5): 665-704\uff0e<\/p>\r\n\r\n\r\n\r\n

2. Sadigh-Eteghad S\uff0cet al\uff0eAmyloid-beta: a crucial factor in Alzheimer\u2019s disease\uff0e Medical Principles and Practice\uff0c 2015\uff0c 24( 1) : 1-10\uff0e<\/p>\r\n\r\n\r\n\r\n

3. Breydo L et al. Structural differences between amyloid beta oligomers\uff0eBiochemical and biophysical research communications\uff0c 2016\uff0c 477( 4) : 700-705\uff0e<\/p>\r\n\r\n\r\n\r\n

4. Manczak M et al\uff0e Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer\u2019s disease<\/a>\uff0e Human molecular genetics\uff0c 2016\uff0c 25( 23) : 5148-5166\uff0e<\/p>\r\n\r\n\r\n\r\n

5. Sciacca MF\uff0cet al\uff0e The active role of Ca2+<\/sup> ions in A\u03b2-mediated membrane damage\uff0eChemical Communications\uff0c 2018\uff0c 54( 29) : 3629-3631\uff0e<\/p>\r\n\r\n\r\n\r\n

6. Jack et al.<\/a> Suspectednon-Alzheimer disease pathophysiology–concept and controversy. \u00a0Nat Rev Neurol.2016 Feb;12(2):117-24.<\/p>\r\n\r\n\r\n\r\n

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8. Mattsson-Carlgren et al<\/em>., Ab deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer\u2019s disease\u00a0 Sci. Adv. <\/em>2020; 6 <\/strong>: eaaz2387 15 April 2020.<\/p>\r\n\r\n\r\n\r\n

9. Chris Ho Ching Yeung et al. Amyloid, tau and risk of Alzheimer’s disease: a Mendelian randomization study.Eur J Epidemiol\u00a02021 Jan;36(1):81-88.\u00a0doi: 10.1007\/s10654-020-00683-8.\u00a0Epub 2020 Sep 14.<\/p>\r\n\r\n\r\n\r\n

10. Marc Aurel Busche et al. Nat Neurosci.Synergy between amyloid-\u03b2 and tau in Alzheimer’s disease.\u00a02020 Oct;23(10):1183-1193.<\/p>\r\n","protected":false},"excerpt":{"rendered":"

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